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TAB1-C22ORF42 Fusion FISH Probe

The TAB1-C22ORF42 Fusion FISH Probe is used to confirm a fusion of the TAB1 and C22ORF42 genes. The fusion of the TAB1 and C22ORF42 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TAB1-C22ORF42-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TAB1-C22ORF42-20-RERE 20 (40 μL) 200 μL
TAB1-C22ORF42-20-REOR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-REGO 20 (40 μL) 200 μL
TAB1-C22ORF42-20-REGR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-REAQ 20 (40 μL) 200 μL
TAB1-C22ORF42-20-ORRE 20 (40 μL) 200 μL
TAB1-C22ORF42-20-OROR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-ORGO 20 (40 μL) 200 μL
TAB1-C22ORF42-20-ORAQ 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GORE 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GOOR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GOGO 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GOGR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GOAQ 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GRRE 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GROR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GRGO 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GRGR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-GRAQ 20 (40 μL) 200 μL
TAB1-C22ORF42-20-AQRE 20 (40 μL) 200 μL
TAB1-C22ORF42-20-AQOR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-AQGO 20 (40 μL) 200 μL
TAB1-C22ORF42-20-AQGR 20 (40 μL) 200 μL
TAB1-C22ORF42-20-AQAQ 20 (40 μL) 200 μL

TAB1 Gene Summary

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Name: TGF-beta Activated Kinase 1 (MAP3K7) Binding Protein 1

Chromosome: CHR22: 39795758 -39833132

Locus: 22q13.1

C22orf42 Gene Summary

The Chromosome 22 Open Reading Frame 42 (C22orf42) gene is located on chr22 :32545518-32555243 at 22q12.3.

Gene Name: Chromosome 22 Open Reading Frame 42

Chromosome: CHR22: 32545518 -32555243

Locus: 22q12.3

Gene Diseases

The TAB1 C22ORF42 Fusion has been associated with the following diseases:

Disease Name
Uterine Carcinosarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.