TAB3-DMD Fusion FISH Probe
The TAB3-DMD Fusion FISH Probe is used to confirm a fusion of the TAB3 and DMD genes. The fusion of the TAB3 and DMD genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAB3-DMD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-RERE | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-REOR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-REGO | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-REGR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-REAQ | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-ORRE | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-OROR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-ORGO | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GORE | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GOOR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GOGO | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GOGR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GRRE | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GROR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GRGO | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GRGR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-AQRE | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-AQOR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-AQGO | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-AQGR | 20 (40 μL) | 200 μL |
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| TAB3-DMD-20-AQAQ | 20 (40 μL) | 200 μL |
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DMD Gene Summary
This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]
Gene Name: Dystrophin
Chromosome: CHRX: 31137344 -33357726
Locus: Xp21.2-p21.1
TAB3 Gene Summary
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: TGF-beta Activated Kinase 1 And MAP3K7 Binding Protein 3
Chromosome: CHRX: 30845558 -30907511
Locus: Xp21.2
Gene Diseases
The TAB3 DMD Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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