TAF3-APP Fusion FISH Probe
The TAF3-APP Fusion FISH Probe is used to confirm a fusion of the TAF3 and APP genes. The fusion of the TAF3 and APP genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAF3-APP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-RERE | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-REOR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-REGO | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-REGR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-REAQ | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-ORRE | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-OROR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-ORGO | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GORE | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GOOR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GOGO | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GOGR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GRRE | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GROR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GRGO | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GRGR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-AQRE | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-AQOR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-AQGO | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-AQGR | 20 (40 μL) | 200 μL |
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| TAF3-APP-20-AQAQ | 20 (40 μL) | 200 μL |
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APP Gene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Gene Name: Amyloid Beta Precursor Protein
Chromosome: CHR21: 27252860 -27543446
Locus: 21q21.3
TAF3 Gene Summary
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
Gene Name: TATA-box Binding Protein Associated Factor 3
Chromosome: CHR10: 7860672 -8056714
Locus: 10p14
Gene Diseases
The TAF3 APP Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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