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TAF4-STX16 Fusion FISH Probe

The TAF4-STX16 Fusion FISH Probe is used to confirm a fusion of the TAF4 and STX16 genes. The fusion of the TAF4 and STX16 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TAF4-STX16-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TAF4-STX16-20-RERE 20 (40 μL) 200 μL
TAF4-STX16-20-REOR 20 (40 μL) 200 μL
TAF4-STX16-20-REGO 20 (40 μL) 200 μL
TAF4-STX16-20-REGR 20 (40 μL) 200 μL
TAF4-STX16-20-REAQ 20 (40 μL) 200 μL
TAF4-STX16-20-ORRE 20 (40 μL) 200 μL
TAF4-STX16-20-OROR 20 (40 μL) 200 μL
TAF4-STX16-20-ORGO 20 (40 μL) 200 μL
TAF4-STX16-20-ORAQ 20 (40 μL) 200 μL
TAF4-STX16-20-GORE 20 (40 μL) 200 μL
TAF4-STX16-20-GOOR 20 (40 μL) 200 μL
TAF4-STX16-20-GOGO 20 (40 μL) 200 μL
TAF4-STX16-20-GOGR 20 (40 μL) 200 μL
TAF4-STX16-20-GOAQ 20 (40 μL) 200 μL
TAF4-STX16-20-GRRE 20 (40 μL) 200 μL
TAF4-STX16-20-GROR 20 (40 μL) 200 μL
TAF4-STX16-20-GRGO 20 (40 μL) 200 μL
TAF4-STX16-20-GRGR 20 (40 μL) 200 μL
TAF4-STX16-20-GRAQ 20 (40 μL) 200 μL
TAF4-STX16-20-AQRE 20 (40 μL) 200 μL
TAF4-STX16-20-AQOR 20 (40 μL) 200 μL
TAF4-STX16-20-AQGO 20 (40 μL) 200 μL
TAF4-STX16-20-AQGR 20 (40 μL) 200 μL
TAF4-STX16-20-AQAQ 20 (40 μL) 200 μL

TAF4 Gene Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]

Gene Name: TATA-box Binding Protein Associated Factor 4

Chromosome: CHR20: 60549853 -60640866

Locus: 20q13.33

STX16 Gene Summary

This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]

Gene Name: Syntaxin 16

Chromosome: CHR20: 57226308 -57254582

Locus: 20q13.32

Gene Diseases

The TAF4 STX16 Fusion has been associated with the following diseases:

Disease Name
Head And Neck Squamous Cell Carcinoma 

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.