TANK-CACNB4 Fusion FISH Probe
The TANK-CACNB4 Fusion FISH Probe is used to confirm a fusion of the TANK and CACNB4 genes. The fusion of the TANK and CACNB4 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TANK-CACNB4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-RERE | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-REOR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-REGO | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-REGR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-REAQ | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-ORRE | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-OROR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-ORGO | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-ORAQ | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GORE | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GOOR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GOGO | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GOGR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GOAQ | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GRRE | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GROR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GRGO | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GRGR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-GRAQ | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-AQRE | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-AQOR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-AQGO | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-AQGR | 20 (40 μL) | 200 μL |
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| TANK-CACNB4-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNB4 Gene Summary
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5. [provided by RefSeq, Aug 2016]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Beta 4
Chromosome: CHR2: 152689285 -152955593
Locus: 2q23.3
TANK Gene Summary
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Name: TRAF Family Member Associated NFKB Activator
Chromosome: CHR2: 161993465 -162092682
Locus: 2q24.2
Gene Diseases
The TANK CACNB4 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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