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TBL1XR1-ROCK1 Fusion FISH Probe

The TBL1XR1-ROCK1 Fusion FISH Probe is used to confirm a fusion of the TBL1XR1 and ROCK1 genes. The fusion of the TBL1XR1 and ROCK1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TBL1XR1-ROCK1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-RERE 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-REOR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-REGO 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-REGR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-REAQ 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-ORRE 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-OROR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-ORGO 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-ORAQ 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GORE 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GOOR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GOGO 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GOGR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GOAQ 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GRRE 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GROR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GRGO 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GRGR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-GRAQ 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-AQRE 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-AQOR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-AQGO 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-AQGR 20 (40 μL) 200 μL
TBL1XR1-ROCK1-20-AQAQ 20 (40 μL) 200 μL

ROCK1 Gene Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]

Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1

Chromosome: CHR18: 18529702 -18691812

Locus: 18q11.1

TBL1XR1 Gene Summary

This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]

Gene Name: Transducin Beta Like 1 X-linked Receptor 1

Chromosome: CHR3: 176738541 -176915048

Locus: 3q26.32

Gene Diseases

The TBL1XR1 ROCK1 Fusion has been associated with the following diseases:

Disease Name
Stomach Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.