TBL1XR1-TP73 Fusion FISH Probe
The TBL1XR1-TP73 Fusion FISH Probe is used to confirm a fusion of the TBL1XR1 and TP73 genes. The fusion of the TBL1XR1 and TP73 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBL1XR1-TP73-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-RERE | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-REOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-REGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-REGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-REAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-ORRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-OROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-ORGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GORE | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GOOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GOGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GOGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GRRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GRGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GRGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-AQRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-AQOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-AQGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-AQGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-TP73-20-AQAQ | 20 (40 μL) | 200 μL |
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TP73 Gene Summary
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Gene Name: Tumor Protein P73
Chromosome: CHR1: 3569128 -3652765
Locus: 1p36.32
TBL1XR1 Gene Summary
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Gene Name: Transducin Beta Like 1 X-linked Receptor 1
Chromosome: CHR3: 176738541 -176915048
Locus: 3q26.32
Gene Diseases
The TBL1XR1 TP73 Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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