TBP-FAM120B Fusion FISH Probe
The TBP-FAM120B Fusion FISH Probe is used to confirm a fusion of the TBP and FAM120B genes. The fusion of the TBP and FAM120B genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBP-FAM120B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-RERE | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-REOR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-REGO | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-REGR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-REAQ | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-ORRE | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-OROR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-ORGO | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GORE | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GOOR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GOGO | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GOGR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GRRE | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GROR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GRGO | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GRGR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-AQRE | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-AQOR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-AQGO | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-AQGR | 20 (40 μL) | 200 μL |
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| TBP-FAM120B-20-AQAQ | 20 (40 μL) | 200 μL |
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TBP Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Gene Name: TATA-box Binding Protein
Chromosome: CHR6: 170863420 -170881958
Locus: 6q27
FAM120B Gene Summary
The Family With Sequence Similarity 120B (FAM120B) gene is located on chr6 :170615843-170714237 at 6q27.
Gene Name: Family With Sequence Similarity 120B
Chromosome: CHR6: 170615843 -170714237
Locus: 6q27
Gene Diseases
The TBP FAM120B Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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