TGFB1-FXYD5 Fusion FISH Probe
The TGFB1-FXYD5 Fusion FISH Probe is used to confirm a fusion of the TGFB1 and FXYD5 genes. The fusion of the TGFB1 and FXYD5 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TGFB1-FXYD5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-RERE | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-REOR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-REGO | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-REGR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-REAQ | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-ORRE | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-OROR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-ORGO | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-ORAQ | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GORE | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GOOR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GOGO | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GOGR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GOAQ | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GRRE | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GROR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GRGO | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GRGR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-GRAQ | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-AQRE | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-AQOR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-AQGO | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-AQGR | 20 (40 μL) | 200 μL |
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| TGFB1-FXYD5-20-AQAQ | 20 (40 μL) | 200 μL |
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TGFB1 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Gene Name: Transforming Growth Factor Beta 1
Chromosome: CHR19: 41836811 -41859831
Locus: 19q13.2
FXYD5 Gene Summary
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
Gene Name: FXYD Domain Containing Ion Transport Regulator 5
Chromosome: CHR19: 35645624 -35660788
Locus: 19q13.12
Gene Diseases
The TGFB1 FXYD5 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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