TICAM1-IL12RB1 Fusion FISH Probe
The TICAM1-IL12RB1 Fusion FISH Probe is used to confirm a fusion of the TICAM1 and IL12RB1 genes. The fusion of the TICAM1 and IL12RB1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TICAM1-IL12RB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-RERE | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-REOR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-REGO | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-REGR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-REAQ | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-ORRE | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-OROR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-ORGO | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GORE | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GOOR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GOGO | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GOGR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GRRE | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GROR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GRGO | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GRGR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-AQRE | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-AQOR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-AQGO | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-AQGR | 20 (40 μL) | 200 μL |
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| TICAM1-IL12RB1-20-AQAQ | 20 (40 μL) | 200 μL |
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IL12RB1 Gene Summary
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: Interleukin 12 Receptor Subunit Beta 1
Chromosome: CHR19: 18170370 -18197697
Locus: 19p13.11
TICAM1 Gene Summary
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
Gene Name: Toll Like Receptor Adaptor Molecule 1
Chromosome: CHR19: 4815937 -4831737
Locus: 19p13.3
Gene Diseases
The TICAM1 IL12RB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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