TJP2-FXN Fusion FISH Probe
The TJP2-FXN Fusion FISH Probe is used to confirm a fusion of the TJP2 and FXN genes. The fusion of the TJP2 and FXN genes has been associated with Testicular Germ Cell Tumors, Bladder Urothelial Carcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TJP2-FXN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-RERE | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-REOR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-REGO | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-REGR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-REAQ | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-ORRE | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-OROR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-ORGO | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-ORAQ | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GORE | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GOOR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GOGO | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GOGR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GOAQ | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GRRE | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GROR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GRGO | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GRGR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-GRAQ | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-AQRE | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-AQOR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-AQGO | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-AQGR | 20 (40 μL) | 200 μL |
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| TJP2-FXN-20-AQAQ | 20 (40 μL) | 200 μL |
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FXN Gene Summary
This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Gene Name: Frataxin
Chromosome: CHR9: 71650478 -71715094
Locus: 9q21.11
TJP2 Gene Summary
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Tight Junction Protein 2
Chromosome: CHR9: 71736223 -71870124
Locus: 9q21.11
Gene Diseases
The TJP2 FXN Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
| Bladder Urothelial Carcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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