TJP3-LRRC8E Fusion FISH Probe
The TJP3-LRRC8E Fusion FISH Probe is used to confirm a fusion of the TJP3 and LRRC8E genes. The fusion of the TJP3 and LRRC8E genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TJP3-LRRC8E-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-RERE | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-REOR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-REGO | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-REGR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-REAQ | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-ORRE | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-OROR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-ORGO | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-ORAQ | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GORE | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GOOR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GOGO | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GOGR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GOAQ | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GRRE | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GROR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GRGO | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GRGR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-GRAQ | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-AQRE | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-AQOR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-AQGO | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-AQGR | 20 (40 μL) | 200 μL |
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| TJP3-LRRC8E-20-AQAQ | 20 (40 μL) | 200 μL |
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TJP3 Gene Summary
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Gene Name: Tight Junction Protein 3
Chromosome: CHR19: 3728373 -3750682
Locus: 19p13.3
LRRC8E Gene Summary
This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Gene Name: Leucine Rich Repeat Containing 8 VRAC Subunit E
Chromosome: CHR19: 7953389 -7966908
Locus: 19p13.2
Gene Diseases
The TJP3 LRRC8E Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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