TLE3-THAP10 Fusion FISH Probe
The TLE3-THAP10 Fusion FISH Probe is used to confirm a fusion of the TLE3 and THAP10 genes. The fusion of the TLE3 and THAP10 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TLE3-THAP10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-RERE | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-REOR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-REGO | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-REGR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-REAQ | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-ORRE | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-OROR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-ORGO | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-ORAQ | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GORE | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GOOR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GOGO | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GOGR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GOAQ | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GRRE | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GROR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GRGO | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GRGR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-GRAQ | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-AQRE | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-AQOR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-AQGO | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-AQGR | 20 (40 μL) | 200 μL |
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| TLE3-THAP10-20-AQAQ | 20 (40 μL) | 200 μL |
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TLE3 Gene Summary
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Gene Name: Transducin Like Enhancer Of Split 3
Chromosome: CHR15: 70340542 -70390256
Locus: 15q23
THAP10 Gene Summary
This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010]
Gene Name: THAP Domain Containing 10
Chromosome: CHR15: 71173680 -71184772
Locus: 15q23
Gene Diseases
The TLE3 THAP10 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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