TLK1-CAT Fusion FISH Probe
The TLK1-CAT Fusion FISH Probe is used to confirm a fusion of the TLK1 and CAT genes. The fusion of the TLK1 and CAT genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TLK1-CAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-RERE | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-REOR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-REGO | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-REGR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-REAQ | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-ORRE | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-OROR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-ORGO | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GORE | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GOOR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GOGO | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GOGR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GRRE | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GROR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GRGO | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GRGR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-AQRE | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-AQOR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-AQGO | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-AQGR | 20 (40 μL) | 200 μL |
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| TLK1-CAT-20-AQAQ | 20 (40 μL) | 200 μL |
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CAT Gene Summary
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Gene Name: Catalase
Chromosome: CHR11: 34460471 -34493607
Locus: 11p13
TLK1 Gene Summary
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Tousled Like Kinase 1
Chromosome: CHR2: 171847332 -172087824
Locus: 2q31.1
Gene Diseases
The TLK1 CAT Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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