TLK1-KCNH7 Fusion FISH Probe
The TLK1-KCNH7 Fusion FISH Probe is used to confirm a fusion of the TLK1 and KCNH7 genes. The fusion of the TLK1 and KCNH7 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TLK1-KCNH7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-RERE | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-REOR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-REGO | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-REGR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-REAQ | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-ORRE | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-OROR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-ORGO | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-ORAQ | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GORE | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GOOR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GOGO | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GOGR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GOAQ | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GRRE | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GROR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GRGO | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GRGR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-GRAQ | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-AQRE | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-AQOR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-AQGO | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-AQGR | 20 (40 μL) | 200 μL |
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| TLK1-KCNH7-20-AQAQ | 20 (40 μL) | 200 μL |
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TLK1 Gene Summary
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Tousled Like Kinase 1
Chromosome: CHR2: 171847332 -172087824
Locus: 2q31.1
KCNH7 Gene Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Voltage-gated Channel Subfamily H Member 7
Chromosome: CHR2: 163227916 -163695257
Locus: 2q24.2
Gene Diseases
The TLK1 KCNH7 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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