TLK1-SSB Fusion FISH Probe
The TLK1-SSB Fusion FISH Probe is used to confirm a fusion of the TLK1 and SSB genes. The fusion of the TLK1 and SSB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TLK1-SSB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-RERE | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-REOR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-REGO | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-REGR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-REAQ | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-ORRE | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-OROR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-ORGO | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-ORAQ | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GORE | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GOOR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GOGO | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GOGR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GOAQ | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GRRE | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GROR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GRGO | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GRGR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-GRAQ | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-AQRE | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-AQOR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-AQGO | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-AQGR | 20 (40 μL) | 200 μL |
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| TLK1-SSB-20-AQAQ | 20 (40 μL) | 200 μL |
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SSB Gene Summary
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
Gene Name: Sjogren Syndrome Antigen B
Chromosome: CHR2: 170655388 -170668575
Locus: 2q31.1
TLK1 Gene Summary
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Tousled Like Kinase 1
Chromosome: CHR2: 171847332 -172087824
Locus: 2q31.1
Gene Diseases
The TLK1 SSB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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