TLN1-EIF4G1 Fusion FISH Probe
The TLN1-EIF4G1 Fusion FISH Probe is used to confirm a fusion of the TLN1 and EIF4G1 genes. The fusion of the TLN1 and EIF4G1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TLN1-EIF4G1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-RERE | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-REOR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-REGO | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-REGR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-REAQ | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-ORRE | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-OROR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-ORGO | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GORE | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GOOR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GOGO | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GOGR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GRRE | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GROR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GRGO | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GRGR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-AQRE | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-AQOR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-AQGO | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-AQGR | 20 (40 μL) | 200 μL |
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| TLN1-EIF4G1-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4G1 Gene Summary
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 1
Chromosome: CHR3: 184032282 -184053146
Locus: 3q27.1
TLN1 Gene Summary
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Gene Name: Talin 1
Chromosome: CHR9: 35697333 -35732392
Locus: 9p13.3
Gene Diseases
The TLN1 EIF4G1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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