TMC6-UACA Fusion FISH Probe
The TMC6-UACA Fusion FISH Probe is used to confirm a fusion of the TMC6 and UACA genes. The fusion of the TMC6 and UACA genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMC6-UACA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-RERE | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-REOR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-REGO | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-REGR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-REAQ | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-ORRE | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-OROR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-ORGO | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GORE | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GOOR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GOGO | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GOGR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GRRE | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GROR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GRGO | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GRGR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-AQRE | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-AQOR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-AQGO | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-AQGR | 20 (40 μL) | 200 μL |
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| TMC6-UACA-20-AQAQ | 20 (40 μL) | 200 μL |
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TMC6 Gene Summary
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Channel Like 6
Chromosome: CHR17: 76108998 -76128488
Locus: 17q25.3
UACA Gene Summary
This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]
Gene Name: Uveal Autoantigen With Coiled-coil Domains And Ankyrin Repeats
Chromosome: CHR15: 70946892 -71055850
Locus: 15q23
Gene Diseases
The TMC6 UACA Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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