TMCO3-PRKCZ Fusion FISH Probe
The TMCO3-PRKCZ Fusion FISH Probe is used to confirm a fusion of the TMCO3 and PRKCZ genes. The fusion of the TMCO3 and PRKCZ genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMCO3-PRKCZ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-RERE | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-REOR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-REGO | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-REGR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-REAQ | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-ORRE | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-OROR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-ORGO | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GORE | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GOOR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GOGO | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GOGR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GRRE | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GROR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GRGO | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GRGR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-AQRE | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-AQOR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-AQGO | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-AQGR | 20 (40 μL) | 200 μL |
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| TMCO3-PRKCZ-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCZ Gene Summary
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Zeta
Chromosome: CHR1: 1981908 -2116834
Locus: 1p36.33
TMCO3 Gene Summary
This gene encodes a member of the monovalent cation:proton antiporter 2 (CPA2) family of transporter proteins. Members of this family typically couple the export of monovalent cations, such as potassium or sodium, to the import of protons across cellular membranes. Mutations in this gene have been identified in patients with a rare inherited vision defect, cornea guttata with anterior polar cataract. [provided by RefSeq, Mar 2017]
Gene Name: Transmembrane And Coiled-coil Domains 3
Chromosome: CHR13: 114145307 -114204544
Locus: 13q34
Gene Diseases
The TMCO3 PRKCZ Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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