TMED10-PSMD11 Fusion FISH Probe
The TMED10-PSMD11 Fusion FISH Probe is used to confirm a fusion of the TMED10 and PSMD11 genes. The fusion of the TMED10 and PSMD11 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMED10-PSMD11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-RERE | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-REOR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-REGO | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-REGR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-REAQ | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-ORRE | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-OROR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-ORGO | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GORE | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GOOR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GOGO | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GOGR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GRRE | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GROR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GRGO | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GRGR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-AQRE | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-AQOR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-AQGO | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-AQGR | 20 (40 μL) | 200 μL |
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| TMED10-PSMD11-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMD11 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Proteasome 26S Subunit, Non-ATPase 11
Chromosome: CHR17: 30771501 -30808042
Locus: 17q11.2
TMED10 Gene Summary
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane P24 Trafficking Protein 10
Chromosome: CHR14: 75598170 -75643349
Locus: 14q24.3
Gene Diseases
The TMED10 PSMD11 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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