TMED10-TTLL5 Fusion FISH Probe
The TMED10-TTLL5 Fusion FISH Probe is used to confirm a fusion of the TMED10 and TTLL5 genes. The fusion of the TMED10 and TTLL5 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMED10-TTLL5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-RERE | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-REOR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-REGO | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-REGR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-REAQ | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-ORRE | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-OROR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-ORGO | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GORE | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GOOR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GOGO | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GOGR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GRRE | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GROR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GRGO | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GRGR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-AQRE | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-AQOR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-AQGO | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-AQGR | 20 (40 μL) | 200 μL |
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| TMED10-TTLL5-20-AQAQ | 20 (40 μL) | 200 μL |
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TMED10 Gene Summary
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane P24 Trafficking Protein 10
Chromosome: CHR14: 75598170 -75643349
Locus: 14q24.3
TTLL5 Gene Summary
This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
Gene Name: Tubulin Tyrosine Ligase Like 5
Chromosome: CHR14: 76127550 -76421425
Locus: 14q24.3
Gene Diseases
The TMED10 TTLL5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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