TMEM117-COL25A1 Fusion FISH Probe
The TMEM117-COL25A1 Fusion FISH Probe is used to confirm a fusion of the TMEM117 and COL25A1 genes. The fusion of the TMEM117 and COL25A1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMEM117-COL25A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-RERE | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-REOR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-REGO | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-REGR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-REAQ | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-ORRE | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-OROR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-ORGO | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GORE | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GOOR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GOGO | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GOGR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GRRE | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GROR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GRGO | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GRGR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-AQRE | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-AQOR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-AQGO | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-AQGR | 20 (40 μL) | 200 μL |
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| TMEM117-COL25A1-20-AQAQ | 20 (40 μL) | 200 μL |
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TMEM117 Gene Summary
The Transmembrane Protein 117 (TMEM117) gene is located on chr12 :44229961-44783541 at 12q12.
Gene Name: Transmembrane Protein 117
Chromosome: CHR12: 44229961 -44783541
Locus: 12q12
COL25A1 Gene Summary
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Collagen Type XXV Alpha 1 Chain
Chromosome: CHR4: 109734971 -110223799
Locus: 4q25
Gene Diseases
The TMEM117 COL25A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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