TMEM123-CENPP Fusion FISH Probe
The TMEM123-CENPP Fusion FISH Probe is used to confirm a fusion of the TMEM123 and CENPP genes. The fusion of the TMEM123 and CENPP genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMEM123-CENPP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-RERE | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-REOR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-REGO | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-REGR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-REAQ | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-ORRE | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-OROR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-ORGO | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GORE | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GOOR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GOGO | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GOGR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GRRE | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GROR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GRGO | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GRGR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-AQRE | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-AQOR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-AQGO | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-AQGR | 20 (40 μL) | 200 μL |
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| TMEM123-CENPP-20-AQAQ | 20 (40 μL) | 200 μL |
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TMEM123 Gene Summary
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Protein 123
Chromosome: CHR11: 102267055 -102323775
Locus: 11q22.2
CENPP Gene Summary
CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Gene Name: Centromere Protein P
Chromosome: CHR9: 95087740 -95377437
Locus: 9q22.31
Gene Diseases
The TMEM123 CENPP Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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