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TMEM123-MMP7 Fusion FISH Probe

The TMEM123-MMP7 Fusion FISH Probe is used to confirm a fusion of the TMEM123 and MMP7 genes. The fusion of the TMEM123 and MMP7 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TMEM123-MMP7-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TMEM123-MMP7-20-RERE 20 (40 μL) 200 μL
TMEM123-MMP7-20-REOR 20 (40 μL) 200 μL
TMEM123-MMP7-20-REGO 20 (40 μL) 200 μL
TMEM123-MMP7-20-REGR 20 (40 μL) 200 μL
TMEM123-MMP7-20-REAQ 20 (40 μL) 200 μL
TMEM123-MMP7-20-ORRE 20 (40 μL) 200 μL
TMEM123-MMP7-20-OROR 20 (40 μL) 200 μL
TMEM123-MMP7-20-ORGO 20 (40 μL) 200 μL
TMEM123-MMP7-20-ORAQ 20 (40 μL) 200 μL
TMEM123-MMP7-20-GORE 20 (40 μL) 200 μL
TMEM123-MMP7-20-GOOR 20 (40 μL) 200 μL
TMEM123-MMP7-20-GOGO 20 (40 μL) 200 μL
TMEM123-MMP7-20-GOGR 20 (40 μL) 200 μL
TMEM123-MMP7-20-GOAQ 20 (40 μL) 200 μL
TMEM123-MMP7-20-GRRE 20 (40 μL) 200 μL
TMEM123-MMP7-20-GROR 20 (40 μL) 200 μL
TMEM123-MMP7-20-GRGO 20 (40 μL) 200 μL
TMEM123-MMP7-20-GRGR 20 (40 μL) 200 μL
TMEM123-MMP7-20-GRAQ 20 (40 μL) 200 μL
TMEM123-MMP7-20-AQRE 20 (40 μL) 200 μL
TMEM123-MMP7-20-AQOR 20 (40 μL) 200 μL
TMEM123-MMP7-20-AQGO 20 (40 μL) 200 μL
TMEM123-MMP7-20-AQGR 20 (40 μL) 200 μL
TMEM123-MMP7-20-AQAQ 20 (40 μL) 200 μL

MMP7 Gene Summary

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

Gene Name: Matrix Metallopeptidase 7

Chromosome: CHR11: 102391238 -102401478

Locus: 11q22.2

TMEM123 Gene Summary

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

Gene Name: Transmembrane Protein 123

Chromosome: CHR11: 102267055 -102323775

Locus: 11q22.2

Gene Diseases

The TMEM123 MMP7 Fusion has been associated with the following diseases:

Disease Name
Ovarian Serous Cystadenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.