TMEM2-HMCN1 Fusion FISH Probe
The TMEM2-HMCN1 Fusion FISH Probe is used to confirm a fusion of the TMEM2 and HMCN1 genes. The fusion of the TMEM2 and HMCN1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMEM2-HMCN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-RERE | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-REOR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-REGO | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-REGR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-REAQ | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-ORRE | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-OROR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-ORGO | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GORE | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GOOR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GOGO | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GOGR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GRRE | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GROR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GRGO | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GRGR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-AQRE | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-AQOR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-AQGO | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-AQGR | 20 (40 μL) | 200 μL |
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| TMEM2-HMCN1-20-AQAQ | 20 (40 μL) | 200 μL |
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TMEM2 Gene Summary
This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]
Gene Name: Transmembrane Protein 2
Chromosome: CHR9: 74298281 -74383800
Locus: 9q21.13
HMCN1 Gene Summary
This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. [provided by RefSeq, Jul 2008]
Gene Name: Hemicentin 1
Chromosome: CHR1: 185703682 -186160085
Locus: 1q25.3-q31.1
Gene Diseases
The TMEM2 HMCN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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