TMTC2-SOCS2 Fusion FISH Probe
The TMTC2-SOCS2 Fusion FISH Probe is used to confirm a fusion of the TMTC2 and SOCS2 genes. The fusion of the TMTC2 and SOCS2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMTC2-SOCS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-RERE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-REOR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-REGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-REGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-REAQ | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-ORRE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-OROR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-ORGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GORE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GOOR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GOGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GOGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GRRE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GROR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GRGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GRGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQRE | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQOR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQGO | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQGR | 20 (40 μL) | 200 μL |
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| TMTC2-SOCS2-20-AQAQ | 20 (40 μL) | 200 μL |
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SOCS2 Gene Summary
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Name: Suppressor Of Cytokine Signaling 2
Chromosome: CHR12: 93963597 -93969978
Locus: 12q22
TMTC2 Gene Summary
The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Transmembrane And Tetratricopeptide Repeat Containing 2
Chromosome: CHR12: 83080933 -83528067
Locus: 12q21.31
Gene Diseases
The TMTC2 SOCS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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