TNFSF10-NCEH1 Fusion FISH Probe
The TNFSF10-NCEH1 Fusion FISH Probe is used to confirm a fusion of the TNFSF10 and NCEH1 genes. The fusion of the TNFSF10 and NCEH1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNFSF10-NCEH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-RERE | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-REOR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-REGO | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-REGR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-REAQ | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-ORRE | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-OROR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-ORGO | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GORE | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GOOR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GOGO | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GOGR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GRRE | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GROR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GRGO | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GRGR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-AQRE | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-AQOR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-AQGO | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-AQGR | 20 (40 μL) | 200 μL |
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| TNFSF10-NCEH1-20-AQAQ | 20 (40 μL) | 200 μL |
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TNFSF10 Gene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Name: TNF Superfamily Member 10
Chromosome: CHR3: 172223297 -172241297
Locus: 3q26.31
NCEH1 Gene Summary
The Neutral Cholesterol Ester Hydrolase 1 (NCEH1) gene is located on chr3 :172348434-172429008 at 3q26.31.
Gene Name: Neutral Cholesterol Ester Hydrolase 1
Chromosome: CHR3: 172348434 -172429008
Locus: 3q26.31
Gene Diseases
The TNFSF10 NCEH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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