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TNRC18-RNF216 Fusion FISH Probe

The TNRC18-RNF216 Fusion FISH Probe is used to confirm a fusion of the TNRC18 and RNF216 genes. The fusion of the TNRC18 and RNF216 genes has been associated with Lung Adenocarcinoma, Uterine Corpus Endometrial Carcinoma, Uterine Corpus Endometrial Carcinoma, Uterine Corpus Endometrial Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TNRC18-RNF216-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TNRC18-RNF216-20-RERE 20 (40 μL) 200 μL
TNRC18-RNF216-20-REOR 20 (40 μL) 200 μL
TNRC18-RNF216-20-REGO 20 (40 μL) 200 μL
TNRC18-RNF216-20-REGR 20 (40 μL) 200 μL
TNRC18-RNF216-20-REAQ 20 (40 μL) 200 μL
TNRC18-RNF216-20-ORRE 20 (40 μL) 200 μL
TNRC18-RNF216-20-OROR 20 (40 μL) 200 μL
TNRC18-RNF216-20-ORGO 20 (40 μL) 200 μL
TNRC18-RNF216-20-ORAQ 20 (40 μL) 200 μL
TNRC18-RNF216-20-GORE 20 (40 μL) 200 μL
TNRC18-RNF216-20-GOOR 20 (40 μL) 200 μL
TNRC18-RNF216-20-GOGO 20 (40 μL) 200 μL
TNRC18-RNF216-20-GOGR 20 (40 μL) 200 μL
TNRC18-RNF216-20-GOAQ 20 (40 μL) 200 μL
TNRC18-RNF216-20-GRRE 20 (40 μL) 200 μL
TNRC18-RNF216-20-GROR 20 (40 μL) 200 μL
TNRC18-RNF216-20-GRGO 20 (40 μL) 200 μL
TNRC18-RNF216-20-GRGR 20 (40 μL) 200 μL
TNRC18-RNF216-20-GRAQ 20 (40 μL) 200 μL
TNRC18-RNF216-20-AQRE 20 (40 μL) 200 μL
TNRC18-RNF216-20-AQOR 20 (40 μL) 200 μL
TNRC18-RNF216-20-AQGO 20 (40 μL) 200 μL
TNRC18-RNF216-20-AQGR 20 (40 μL) 200 μL
TNRC18-RNF216-20-AQAQ 20 (40 μL) 200 μL

RNF216 Gene Summary

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]

Gene Name: Ring Finger Protein 216

Chromosome: CHR7: 5659671 -5821361

Locus: 7p22.1

TNRC18 Gene Summary

The Trinucleotide Repeat Containing 18 (TNRC18) gene is located on chr7 :5346422-5463177 at 7p22.1.

Gene Name: Trinucleotide Repeat Containing 18

Chromosome: CHR7: 5346422 -5463177

Locus: 7p22.1

Gene Diseases

The TNRC18 RNF216 Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma
Uterine Corpus Endometrial Carcinoma
Uterine Corpus Endometrial Carcinoma
Uterine Corpus Endometrial Carcinoma
Stomach Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.