TOLLIP-MUC5B Fusion FISH Probe
The TOLLIP-MUC5B Fusion FISH Probe is used to confirm a fusion of the TOLLIP and MUC5B genes. The fusion of the TOLLIP and MUC5B genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOLLIP-MUC5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-RERE | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-REOR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-REGO | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-REGR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-REAQ | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-ORRE | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-OROR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-ORGO | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GORE | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GOOR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GOGO | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GOGR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GRRE | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GROR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GRGO | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GRGR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-AQRE | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-AQOR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-AQGO | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-AQGR | 20 (40 μL) | 200 μL |
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| TOLLIP-MUC5B-20-AQAQ | 20 (40 μL) | 200 μL |
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TOLLIP Gene Summary
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: Toll Interacting Protein
Chromosome: CHR11: 1295597 -1330892
Locus: 11p15.5
MUC5B Gene Summary
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
Gene Name: Mucin 5B, Oligomeric Mucus/gel-forming
Chromosome: CHR11: 1244294 -1283406
Locus: 11p15.5
Gene Diseases
The TOLLIP MUC5B Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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