TOM1L2-ATPAF2 Fusion FISH Probe
The TOM1L2-ATPAF2 Fusion FISH Probe is used to confirm a fusion of the TOM1L2 and ATPAF2 genes. The fusion of the TOM1L2 and ATPAF2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOM1L2-ATPAF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-RERE | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-REOR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-REGO | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-REGR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-REAQ | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-ORRE | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-OROR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-ORGO | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GORE | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GOOR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GOGO | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GOGR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GRRE | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GROR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GRGO | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GRGR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-AQRE | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-AQOR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-AQGO | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-AQGR | 20 (40 μL) | 200 μL |
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| TOM1L2-ATPAF2-20-AQAQ | 20 (40 μL) | 200 μL |
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ATPAF2 Gene Summary
This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 alpha subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. This gene is located within the Smith-Magenis syndrome region on chromosome 17. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: ATP Synthase Mitochondrial F1 Complex Assembly Factor 2
Chromosome: CHR17: 17921333 -17942480
Locus: 17p11.2
TOM1L2 Gene Summary
This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]
Gene Name: Target Of Myb1 Like 2 Membrane Trafficking Protein
Chromosome: CHR17: 17746821 -17875784
Locus: 17p11.2
Gene Diseases
The TOM1L2 ATPAF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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