TOM1L2-NXN Fusion FISH Probe
The TOM1L2-NXN Fusion FISH Probe is used to confirm a fusion of the TOM1L2 and NXN genes. The fusion of the TOM1L2 and NXN genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TOM1L2-NXN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TOM1L2-NXN-20-AQAQ | 20 (40 μL) | 200 μL |
|
NXN Gene Summary
This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
Gene Name: Nucleoredoxin
Chromosome: CHR17: 702552 -882998
Locus: 17p13.3
TOM1L2 Gene Summary
This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]
Gene Name: Target Of Myb1 Like 2 Membrane Trafficking Protein
Chromosome: CHR17: 17746821 -17875784
Locus: 17p11.2
Gene Diseases
The TOM1L2 NXN Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|