TOP3A-MYO18A Fusion FISH Probe
The TOP3A-MYO18A Fusion FISH Probe is used to confirm a fusion of the TOP3A and MYO18A genes. The fusion of the TOP3A and MYO18A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOP3A-MYO18A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-RERE | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-REOR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-REGO | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-REGR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-REAQ | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-ORRE | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-OROR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-ORGO | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GORE | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GOOR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GOGO | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GOGR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GRRE | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GROR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GRGO | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GRGR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-AQRE | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-AQOR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-AQGO | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-AQGR | 20 (40 μL) | 200 μL |
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| TOP3A-MYO18A-20-AQAQ | 20 (40 μL) | 200 μL |
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TOP3A Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Gene Name: DNA Topoisomerase III Alpha
Chromosome: CHR17: 18177234 -18218321
Locus: 17p11.2
MYO18A Gene Summary
The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]
Gene Name: Myosin XVIIIA
Chromosome: CHR17: 27400527 -27507407
Locus: 17q11.2
Gene Diseases
The TOP3A MYO18A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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