TOX3-PHKB Fusion FISH Probe
The TOX3-PHKB Fusion FISH Probe is used to confirm a fusion of the TOX3 and PHKB genes. The fusion of the TOX3 and PHKB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TOX3-PHKB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-RERE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-REOR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-REGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-REGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-REAQ | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-ORRE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-OROR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-ORGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GORE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GOOR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GOGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GOGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GRRE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GROR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GRGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GRGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQRE | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQOR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQGO | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQGR | 20 (40 μL) | 200 μL |
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| TOX3-PHKB-20-AQAQ | 20 (40 μL) | 200 μL |
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PHKB Gene Summary
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.[provided by RefSeq, Feb 2010]
Gene Name: Phosphorylase Kinase Regulatory Subunit Beta
Chromosome: CHR16: 47495209 -47735434
Locus: 16q12.1
TOX3 Gene Summary
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Gene Name: TOX High Mobility Group Box Family Member 3
Chromosome: CHR16: 52471917 -52581714
Locus: 16q12.1
Gene Diseases
The TOX3 PHKB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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