TP53BP1-STAU2 Fusion FISH Probe
The TP53BP1-STAU2 Fusion FISH Probe is used to confirm a fusion of the TP53BP1 and STAU2 genes. The fusion of the TP53BP1 and STAU2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TP53BP1-STAU2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-RERE | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-REOR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-REGO | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-REGR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-REAQ | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-ORRE | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-OROR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-ORGO | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GORE | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GOOR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GOGO | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GOGR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GRRE | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GROR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GRGO | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GRGR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-AQRE | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-AQOR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-AQGO | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-AQGR | 20 (40 μL) | 200 μL |
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| TP53BP1-STAU2-20-AQAQ | 20 (40 μL) | 200 μL |
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TP53BP1 Gene Summary
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein P53 Binding Protein 1
Chromosome: CHR15: 43699411 -43802707
Locus: 15q15.3
STAU2 Gene Summary
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Gene Name: Staufen Double-stranded RNA Binding Protein 2
Chromosome: CHR8: 74332603 -74659162
Locus: 8q21.11
Gene Diseases
The TP53BP1 STAU2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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