TPST2-CRYBB1 Fusion FISH Probe
The TPST2-CRYBB1 Fusion FISH Probe is used to confirm a fusion of the TPST2 and CRYBB1 genes. The fusion of the TPST2 and CRYBB1 genes has been associated with Uterine Corpus Endometrial Carcinoma, Liver Hepatocellular Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPST2-CRYBB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-RERE | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-REOR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-REGO | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-REGR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-REAQ | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-ORRE | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-OROR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-ORGO | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GORE | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GOOR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GOGO | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GOGR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GRRE | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GROR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GRGO | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GRGR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-AQRE | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-AQOR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-AQGO | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-AQGR | 20 (40 μL) | 200 μL |
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| TPST2-CRYBB1-20-AQAQ | 20 (40 μL) | 200 μL |
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CRYBB1 Gene Summary
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]
Gene Name: Crystallin Beta B1
Chromosome: CHR22: 26995361 -27013991
Locus: 22q12.1
TPST2 Gene Summary
The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosylprotein Sulfotransferase 2
Chromosome: CHR22: 26921713 -26986089
Locus: 22q12.1
Gene Diseases
The TPST2 CRYBB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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