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TPT1-EIF2AK2 Fusion FISH Probe

The TPT1-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the TPT1 and EIF2AK2 genes. The fusion of the TPT1 and EIF2AK2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TPT1-EIF2AK2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-RERE 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-REOR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-REGO 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-REGR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-REAQ 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-ORRE 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-OROR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-ORGO 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-ORAQ 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GORE 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GOOR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GOGO 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GOGR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GOAQ 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GRRE 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GROR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GRGO 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GRGR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-GRAQ 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-AQRE 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-AQOR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-AQGO 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-AQGR 20 (40 μL) 200 μL
TPT1-EIF2AK2-20-AQAQ 20 (40 μL) 200 μL

EIF2AK2 Gene Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2

Chromosome: CHR2: 37333698 -37384190

Locus: 2p22.2

TPT1 Gene Summary

This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Gene Name: Tumor Protein, Translationally-controlled 1

Chromosome: CHR13: 45911303 -45915297

Locus: 13q14.13

Gene Diseases

The TPT1 EIF2AK2 Fusion has been associated with the following diseases:

Disease Name
Stomach Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.