TPT1-SIAE Fusion FISH Probe
The TPT1-SIAE Fusion FISH Probe is used to confirm a fusion of the TPT1 and SIAE genes. The fusion of the TPT1 and SIAE genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TPT1-SIAE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-RERE | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-REOR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-REGO | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-REGR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-REAQ | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-ORRE | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-OROR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-ORGO | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-ORAQ | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GORE | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GOOR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GOGO | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GOGR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GOAQ | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GRRE | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GROR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GRGO | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GRGR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-GRAQ | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-AQRE | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-AQOR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-AQGO | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-AQGR | 20 (40 μL) | 200 μL |
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| TPT1-SIAE-20-AQAQ | 20 (40 μL) | 200 μL |
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TPT1 Gene Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein, Translationally-controlled 1
Chromosome: CHR13: 45911303 -45915297
Locus: 13q14.13
SIAE Gene Summary
This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Sialic Acid Acetylesterase
Chromosome: CHR11: 124505684 -124546199
Locus: 11q24.2
Gene Diseases
The TPT1 SIAE Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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