TRAF3-ITPK1 Fusion FISH Probe
The TRAF3-ITPK1 Fusion FISH Probe is used to confirm a fusion of the TRAF3 and ITPK1 genes. The fusion of the TRAF3 and ITPK1 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRAF3-ITPK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-RERE | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-REOR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-REGO | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-REGR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-REAQ | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-ORRE | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-OROR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-ORGO | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GORE | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GOOR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GOGO | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GOGR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GRRE | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GROR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GRGO | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GRGR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-AQRE | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-AQOR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-AQGO | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-AQGR | 20 (40 μL) | 200 μL |
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| TRAF3-ITPK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPK1 Gene Summary
This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]
Gene Name: Inositol-tetrakisphosphate 1-kinase
Chromosome: CHR14: 93403258 -93582263
Locus: 14q32.12
TRAF3 Gene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]
Gene Name: TNF Receptor Associated Factor 3
Chromosome: CHR14: 103243815 -103377837
Locus: 14q32.32
Gene Diseases
The TRAF3 ITPK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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