TRAF4-FASN Fusion FISH Probe
The TRAF4-FASN Fusion FISH Probe is used to confirm a fusion of the TRAF4 and FASN genes. The fusion of the TRAF4 and FASN genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRAF4-FASN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-RERE | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-REOR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-REGO | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-REGR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-REAQ | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-ORRE | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-OROR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-ORGO | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GORE | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GOOR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GOGO | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GOGR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GRRE | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GROR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GRGO | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GRGR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-AQRE | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-AQOR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-AQGO | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-AQGR | 20 (40 μL) | 200 μL |
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| TRAF4-FASN-20-AQAQ | 20 (40 μL) | 200 μL |
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FASN Gene Summary
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Gene Name: Fatty Acid Synthase
Chromosome: CHR17: 80036213 -80056106
Locus: 17q25.3
TRAF4 Gene Summary
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Gene Name: TNF Receptor Associated Factor 4
Chromosome: CHR17: 27071022 -27077976
Locus: 17q11.2
Gene Diseases
The TRAF4 FASN Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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