TRIB3-SLC24A3 Fusion FISH Probe
The TRIB3-SLC24A3 Fusion FISH Probe is used to confirm a fusion of the TRIB3 and SLC24A3 genes. The fusion of the TRIB3 and SLC24A3 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIB3-SLC24A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-RERE | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-REOR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-REGO | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-REGR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-OROR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GORE | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GROR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIB3-SLC24A3-20-AQAQ | 20 (40 μL) | 200 μL |
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SLC24A3 Gene Summary
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
Gene Name: Solute Carrier Family 24 Member 3
Chromosome: CHR20: 19193289 -19703541
Locus: 20p11.23
TRIB3 Gene Summary
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: Tribbles Pseudokinase 3
Chromosome: CHR20: 361307 -378203
Locus: 20p13
Gene Diseases
The TRIB3 SLC24A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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