TRIM27-PTPRR Fusion FISH Probe
The TRIM27-PTPRR Fusion FISH Probe is used to confirm a fusion of the TRIM27 and PTPRR genes. The fusion of the TRIM27 and PTPRR genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TRIM27-PTPRR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-RERE | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-REOR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-REGO | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-REGR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-REAQ | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-ORRE | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-OROR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-ORGO | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-ORAQ | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GORE | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GOOR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GOGO | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GOGR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GOAQ | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GRRE | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GROR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GRGO | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GRGR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-GRAQ | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-AQRE | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-AQOR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-AQGO | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-AQGR | 20 (40 μL) | 200 μL |
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| TRIM27-PTPRR-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRR Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type R
Chromosome: CHR12: 71031852 -71314584
Locus: 12q15
TRIM27 Gene Summary
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Gene Name: Tripartite Motif Containing 27
Chromosome: CHR6_cox_hap2: 393802 -414796
Locus: 6p22.1
Gene Diseases
The TRIM27 PTPRR Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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