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TRIO-ADAMTS12 Fusion FISH Probe

The TRIO-ADAMTS12 Fusion FISH Probe is used to confirm a fusion of the TRIO and ADAMTS12 genes. The fusion of the TRIO and ADAMTS12 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TRIO-ADAMTS12-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-RERE 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-REOR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-REGO 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-REGR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-REAQ 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-ORRE 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-OROR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-ORGO 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-ORAQ 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GORE 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GOOR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GOGO 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GOGR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GOAQ 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GRRE 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GROR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GRGO 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GRGR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-GRAQ 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-AQRE 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-AQOR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-AQGO 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-AQGR 20 (40 μL) 200 μL
TRIO-ADAMTS12-20-AQAQ 20 (40 μL) 200 μL

TRIO Gene Summary

This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Gene Name: Trio Rho Guanine Nucleotide Exchange Factor

Chromosome: CHR5: 14143828 -14509458

Locus: 5p15.2

ADAMTS12 Gene Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12

Chromosome: CHR5: 33527286 -33892124

Locus: 5p13.3-p13.2

Gene Diseases

The TRIO ADAMTS12 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.