TSPAN3-CFB Fusion FISH Probe
The TSPAN3-CFB Fusion FISH Probe is used to confirm a fusion of the TSPAN3 and CFB genes. The fusion of the TSPAN3 and CFB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TSPAN3-CFB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-RERE | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-REOR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-REGO | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-REGR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-REAQ | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-ORRE | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-OROR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-ORGO | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-ORAQ | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GORE | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GOOR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GOGO | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GOGR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GOAQ | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GRRE | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GROR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GRGO | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GRGR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-GRAQ | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-AQRE | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-AQOR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-AQGO | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-AQGR | 20 (40 μL) | 200 μL |
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| TSPAN3-CFB-20-AQAQ | 20 (40 μL) | 200 μL |
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CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
TSPAN3 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
Gene Name: Tetraspanin 3
Chromosome: CHR15: 77336359 -77363570
Locus: 15q24.3
Gene Diseases
The TSPAN3 CFB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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