TUSC3-HOOK3 Fusion FISH Probe
The TUSC3-HOOK3 Fusion FISH Probe is used to confirm a fusion of the TUSC3 and HOOK3 genes. The fusion of the TUSC3 and HOOK3 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TUSC3-HOOK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-RERE | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-REOR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-REGO | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-REGR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-REAQ | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-ORRE | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-OROR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-ORGO | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GORE | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GOOR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GOGO | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GOGR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GRRE | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GROR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GRGO | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GRGR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-AQRE | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-AQOR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-AQGO | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-AQGR | 20 (40 μL) | 200 μL |
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| TUSC3-HOOK3-20-AQAQ | 20 (40 μL) | 200 μL |
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TUSC3 Gene Summary
This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]
Gene Name: Tumor Suppressor Candidate 3
Chromosome: CHR8: 15397595 -15624158
Locus: 8p22
HOOK3 Gene Summary
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Gene Name: Hook Microtubule Tethering Protein 3
Chromosome: CHR8: 42752032 -42885682
Locus: 8p11.21
Gene Diseases
The TUSC3 HOOK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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