TUSC3-LOXL2 Fusion FISH Probe
The TUSC3-LOXL2 Fusion FISH Probe is used to confirm a fusion of the TUSC3 and LOXL2 genes. The fusion of the TUSC3 and LOXL2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TUSC3-LOXL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-RERE | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-REOR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-REGO | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-REGR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-REAQ | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-ORRE | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-OROR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-ORGO | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GORE | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GOOR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GOGO | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GOGR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GRRE | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GROR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GRGO | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GRGR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-AQRE | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-AQOR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-AQGO | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-AQGR | 20 (40 μL) | 200 μL |
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| TUSC3-LOXL2-20-AQAQ | 20 (40 μL) | 200 μL |
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LOXL2 Gene Summary
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Gene Name: Lysyl Oxidase Like 2
Chromosome: CHR8: 23154409 -23261722
Locus: 8p21.3
TUSC3 Gene Summary
This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]
Gene Name: Tumor Suppressor Candidate 3
Chromosome: CHR8: 15397595 -15624158
Locus: 8p22
Gene Diseases
The TUSC3 LOXL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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