TYK2-SYMPK Fusion FISH Probe
The TYK2-SYMPK Fusion FISH Probe is used to confirm a fusion of the TYK2 and SYMPK genes. The fusion of the TYK2 and SYMPK genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TYK2-SYMPK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-RERE | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-REOR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-REGO | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-REGR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-REAQ | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-ORRE | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-OROR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-ORGO | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-ORAQ | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GORE | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GOOR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GOGO | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GOGR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GOAQ | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GRRE | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GROR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GRGO | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GRGR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-GRAQ | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-AQRE | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-AQOR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-AQGO | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-AQGR | 20 (40 μL) | 200 μL |
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| TYK2-SYMPK-20-AQAQ | 20 (40 μL) | 200 μL |
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TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
SYMPK Gene Summary
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
Gene Name: Symplekin
Chromosome: CHR19: 46318699 -46366548
Locus: 19q13.32
Gene Diseases
The TYK2 SYMPK Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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