UACA-PTPN6 Fusion FISH Probe
The UACA-PTPN6 Fusion FISH Probe is used to confirm a fusion of the UACA and PTPN6 genes. The fusion of the UACA and PTPN6 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UACA-PTPN6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-RERE | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-REOR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-REGO | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-REGR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-OROR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GORE | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GROR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| UACA-PTPN6-20-AQAQ | 20 (40 μL) | 200 μL |
|
PTPN6 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 6
Chromosome: CHR12: 7055739 -7070479
Locus: 12p13.31
UACA Gene Summary
This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]
Gene Name: Uveal Autoantigen With Coiled-coil Domains And Ankyrin Repeats
Chromosome: CHR15: 70946892 -71055850
Locus: 15q23
Gene Diseases
The UACA PTPN6 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|