UBA2-GPI Fusion FISH Probe
The UBA2-GPI Fusion FISH Probe is used to confirm a fusion of the UBA2 and GPI genes. The fusion of the UBA2 and GPI genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBA2-GPI-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-RERE | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-REOR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-REGO | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-REGR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-REAQ | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-ORRE | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-OROR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-ORGO | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GORE | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GOOR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GOGO | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GOGR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GRRE | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GROR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GRGO | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GRGR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-AQRE | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-AQOR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-AQGO | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-AQGR | 20 (40 μL) | 200 μL |
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| UBA2-GPI-20-AQAQ | 20 (40 μL) | 200 μL |
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GPI Gene Summary
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: Glucose-6-phosphate Isomerase
Chromosome: CHR19: 34855644 -34893318
Locus: 19q13.11
UBA2 Gene Summary
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Gene Name: Ubiquitin Like Modifier Activating Enzyme 2
Chromosome: CHR19: 34919267 -34960798
Locus: 19q13.11
Gene Diseases
The UBA2 GPI Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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