UBA6-TMPRSS11D Fusion FISH Probe
The UBA6-TMPRSS11D Fusion FISH Probe is used to confirm a fusion of the UBA6 and TMPRSS11D genes. The fusion of the UBA6 and TMPRSS11D genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBA6-TMPRSS11D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-RERE | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-REOR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-REGO | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-REGR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-REAQ | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-ORRE | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-OROR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-ORGO | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GORE | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GOOR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GOGO | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GOGR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GRRE | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GROR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GRGO | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GRGR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-AQRE | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-AQOR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-AQGO | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-AQGR | 20 (40 μL) | 200 μL |
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| UBA6-TMPRSS11D-20-AQAQ | 20 (40 μL) | 200 μL |
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TMPRSS11D Gene Summary
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Protease, Serine 11D
Chromosome: CHR4: 68686593 -68749716
Locus: 4q13.2
UBA6 Gene Summary
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]
Gene Name: Ubiquitin Like Modifier Activating Enzyme 6
Chromosome: CHR4: 68481478 -68566889
Locus: 4q13.2
Gene Diseases
The UBA6 TMPRSS11D Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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