UBE2D2-CTNNA1 Fusion FISH Probe
The UBE2D2-CTNNA1 Fusion FISH Probe is used to confirm a fusion of the UBE2D2 and CTNNA1 genes. The fusion of the UBE2D2 and CTNNA1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2D2-CTNNA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2D2-CTNNA1-20-AQAQ | 20 (40 μL) | 200 μL |
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CTNNA1 Gene Summary
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]
Gene Name: Catenin Alpha 1
Chromosome: CHR5: 138089106 -138270723
Locus: 5q31.2
UBE2D2 Gene Summary
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Name: Ubiquitin Conjugating Enzyme E2 D2
Chromosome: CHR5: 138940750 -139008018
Locus: 5q31.2
Gene Diseases
The UBE2D2 CTNNA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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